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Somatostatin analogs (SSTs) have potent antitumor activity in several cancer types, but the mechanisms by which they exert this activity are not fully understood. We have recently shown that a SST analog, SOM230, is highly effective in a mouse model of colon carcinoma, where it can cause tumor regression. In this study, we demonstrate that tumor regression caused by SOM230 in the mouse is associated with enhanced tumor cell apoptosis and inhibition of cell proliferation, and we also show that SOM230 induces apoptosis in colon cancer cells. In addition, SOM230 suppresses the expression of COX-2, an enzyme that is known to be upregulated in human colon cancer and which has a role in the regulation of apoptosis and cell-cycle progression. The effect of SOM230 on cell-cycle progression is also associated with a reduction of cyclin-dependent kinases. 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The faculty is comprised of the 5 Scientific Research Cores, a Clinical Research Training and Mentorship Program, a What's New In Classic Sports Cars Theme? System Requirements For Classic Sports Cars Theme: Minimum: OS: Windows XP, Vista, 7, 8, 8.1, 10 (32-bit or 64-bit) Processor: Intel Core 2 Duo 2.0 GHz or AMD Athlon X2 2.0 GHz Memory: 2 GB DirectX: Version 9.0 Storage: 30 MB available space Additional Notes: Hardware Requirements: CPU: Intel Core 2 Duo 2.0 GHz or AMD Athlon X2 2.0 GHz Graphics: NVIDIA
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